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A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. There are no data with Augmentin and allopurinol administered concurrently. After you have been taking allopurinol regularly for several months, the attacks may stop completely. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated.
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