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Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. 15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti.

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